PTCOG 61 Research Highlight: Benefits of Proton Reirradiation

The New York Proton Center recently took a leading part in the annual PTCOG (Particle Therapy Co-Operative Group) meeting in Madrid, Spain. Many of NYPC’s radiation oncologists and medical physicists gave talks on a wide variety of topics and had presentations on their research. Among them was Chief Medical Officer Dr. Charles B. Simone, II, who leveraged some of his latest industry-leading research to host a number of sessions and give keynote and plenary session talks on proton therapy reirradiation.

Reducing the Risks of Cumulative Toxicity

Reirradiation is an excellent option for many patients whose cancer returns or progresses after initial radiation treatment. Proton therapy, an advanced form of radiation treatment with unique properties, has proven to be highly suitable for treating recurrent cancer, and it enables precise targeting of tumors while better minimizing damage to surrounding healthy tissues.

Proton therapy sets itself apart from conventional radiation therapy by delivering maximum radiation directly to the tumor while sparing healthy tissues beyond the target area. This precision is especially advantageous in reirradiation cases where tumors may be located near critical structures that have already been exposed to radiation during their initial treatment course. For patients who have undergone previous radiation therapy, proton therapy often offers patients their only chance of cure while reducing the risks of cumulative toxicity.

Spearheading Research in Proton Therapy Reirradiation

The New York Proton Center has a significant focus on recurrent cancer, with 43% of patients receiving reirradiation, in contrast to the national average of 11% among other U.S. proton centers. NYPC specializes in reirradiation for various recurrent cancers, including colorectal and other gastrointestinal cancers, breast cancer, lung and other thoracic cancers, prostate cancer, head and neck cancers, brain tumors, and sarcomas. The Center has been at the forefront of proton therapy reirradiation research, spearheading numerous studies, including the most comprehensive reirradiation clinical trial to date.

Reirradiation with proton therapy offers hope and the potential for long-term tumor control, even when other treatment options have been exhausted. Proton therapy plays a leading role in reirradiation, offering unparalleled outcomes. Its ability to precisely target tumors and spare healthy tissues makes it an invaluable tool in the fight against cancer and a game-changer for patients with who experience a cancer recurrence. As the medical field continues to advance, proton therapy is expected to play an increasingly vital role in the comprehensive care of cancer patients, particularly those in need of reirradiation. NYPC is committed to raising public awareness of the immense benefits of proton therapy and aims to further research around proton therapy reirradiation to ensure it becomes more accessible to all who could benefit from it.

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Targeting Brain Tumors with Proton Therapy

Every year, approximately 90,000 people are diagnosed with a primary brain tumor according to the American Brain Tumor Association (ABTA). In addition, brain and central nervous system (CNS) tumors are the most common cancer diagnosed in children aged 0-14 and are the leading cause of death among kids.

While great strides have been made in treating brain tumors, there is still more work needed to be done to improve long-term survival rates. On November 10, 2024, the ABTA’s 12th annual New York City Breakthrough for Brain Tumors 5K Run and Walk celebrated these gains and raised funds for vital research and patient support services. The New York Proton Center (NYPC) was thrilled to be a local sponsor of this uplifting event attended by more than 1,000 passionate supporters from throughout the community, including survivors and their family and friends, corporate teams, and healthcare professionals. 

NYPC Radiation Oncologist Irini Yacoub, MD, was a speaker during a panel discussion that took place just prior to the start of the 5K. Dr. Yacoub, whose specialties include treatment of brain tumors, head and neck tumors, and prostate cancer, explained, “With proton therapy, we can better target brain tumors without harming nearby healthy and sensitive tissues in the brain.” She added, “This is because the proton beam deposits nearly all of its energy precisely inside the tumor, with no ‘exit dose’ behind it. Because of this precision, proton therapy can have a much lower risk of short- and long-term side effects such as neurological deficits and intellectual impairment.”

At the New York Proton Center, we treat patients with some of the most complex brain and CNS tumors. We also treat patients with recurrent brain tumors who have received radiation in the past. With proton therapy, we can deliver a second course of radiation more safely while sparing very critical organs that have been previously irradiated.  We join the ABTA in advancing the treatment of these tumors and in providing essential care and resources for patients and their loved ones.

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Proton Therapy: An Effective Treatment for Prostate Cancer

The New York Proton Center is proud to be a sponsor of the 2024 ZERO Prostate Cancer Run/Walk in New York City – a crucial funding source for prostate cancer awareness, research, and patient support. Over the past fifteen years, ZERO has raised more than $32 million, and more than 170,000 runners and walkers have participated in events to provide support to more than 200,000 men across the country who have experienced prostate cancer. We have been proud to participate in this event for four years, and to raise awareness of proton therapy for prostate cancer.

An important treatment option for prostate cancer is 5-fraction SBRT (stereotactic body radiation therapy) proton therapy. Approximately one in eight men will be diagnosed with prostate cancer during their lifetime, and as technology and medicine have advanced, 5-fraction SBRT proton therapy has emerged as an effective treatment option offering ultra-precise radiation therapy that safely delivers a higher dose of radiation per session over just five days, with sessions every other day. 

Compared to more invasive, longer treatments, 5-fraction SBRT proton therapy offers exceptional precision by using pencil beam scanning technology and sending protons directly to the tumor site, sparing surrounding healthy tissues and protecting vital organs. The efficacy of 5-fraction SBRT is comparable to the standard prolonged course of proton therapy, giving patients optimal care without a lengthy treatment schedule. Because of the precision of the radiation as well as the shortened treatment period, patients can complete therapy more efficiently and experience milder or even no side effects. 

While many cancer centers offer photon-based SBRT like CyberKnife, and many proton centers routinely treat prostate cancer, only a handful of centers in the world, including NYPC, offer both the 5-fraction course with the ultra-precision of proton therapy. The use of 5-fraction proton SBRT is a significant milestone in the field of prostate cancer therapy and helps ensure people have expanded treatment options once they receive a diagnosis. 

With prostate cancer being the most common non-skin malignancy diagnosed in men, it’s critical that men have the information they need to stay healthy and get the treatment that works best for them. Learn more by visiting us at the Run/Walk on September 7 at our information table and inside the Messages of Hope & Remembrance Tent. We also encourage you to read about the benefits of proton therapy for prostate cancer.

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