Charles B. Simone, II, MD, FACRO

Chief Medical Officer

Dr. Charles B. Simone, II is the Chief Medical Officer of the New York Proton Center. He is an internationally recognized expert in the use of proton therapy to treat thoracic malignancies and for reirradiation, and in the development of clinical trial strategies and innovative research in thoracic radiation oncology and stereotactic body radiation therapy. He is a National Institutes of Health, National Science Foundation, and Department of Defense funded investigator who performs clinical and translational research investigating the benefits of proton therapy as part of multi-modality therapy for thoracic malignancies. After years of dedication and service to the American College of Radiation Oncologists, Dr. Simone has been named a Fellow of ACRO, recognizing his highly valued contributions to the field.


Prior to coming to NYPC, Dr. Simone was Chief of the Thoracic Oncology Service at the Hospital of the University of Pennsylvania and the Director of the Penn Mesothelioma and Pleural Program. He was then appointment the Medical Director of the Maryland Proton Treatment Center, and at University of Maryland he also served as Chair of the Clinical Research Committee for their Comprehensive Cancer Center, the proton therapy Fellowship Director, and the Director of the Stereotactic Radiation Therapy Program. He completed his undergraduate and medical school training at the University of Pennsylvania. He completed his internship in internal medicine and then residency training in radiation oncology at the National Cancer Institute, National Institutes of Health, where he served as chief resident.


He has published >280 peer-reviewed scientific articles and book chapters and given >185 scientific lectures to national and international audiences. He is the Chair of the Proton Collaborative Group (PCG) Executive Committee, Chair of the PCG Lung Committee, Chair of the American Society for Radiation Oncology (ASTRO) Lung Resource Panel Committee, and Chair of the American Society for Photobiology (ASP) Education Committee. He is also the Editor-in-Chief of Annals of Palliative Medicine.




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