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Charles B. Simone, II, MD, FACRO

Chief Medical Officer

Charles B. Simone, II, MD, FACRO is a Research Professor and the Chief Medical Officer of the New York Proton Center. He is also a Full Member in the Department of Radiation Oncology at Memorial Sloan Kettering Cancer Center. He is an internationally recognized expert in the use of proton therapy to treat thoracic malignancies and for reirradiation, and in the development of clinical trial strategies and innovative research in thoracic radiation oncology and stereotactic body radiation therapy using traditional radiation therapy. He is a National Institutes of Health, National Science Foundation, and Department of Defense funded investigator who performs clinical and translational research investigating the benefits of proton therapy and traditional radiation therapy as part of multi-modality therapy for lung cancer, malignant pleural mesothelioma, thymic tumors, and other thoracic malignancies.


Prior to coming to the New York Proton Center, Dr. Simone was Chief of the Thoracic Oncology Service at the Hospital of the University of Pennsylvania, Director of the Penn Mesothelioma and Pleural Program, and Director of Clinical Research and Operations in the Department of Radiation Oncology at Penn.  He was then appointed Medical Director of the Maryland Proton Treatment Center, and at the University of Maryland, he also served as Chair of the Clinical Research Committee for their Comprehensive Cancer Center, proton therapy Fellowship Director, and Director of the Stereotactic Radiation Therapy Program. He completed his undergraduate and medical school training at the University of Pennsylvania, internship in internal medicine, and residency training in radiation oncology at the National Cancer Institute, NIH, where he served as chief resident.


Dr. Simone has published >480 peer-reviewed scientific articles and book chapters, given >385 scientific lectures to national and international audiences, and is the national Principal Investigator or Co-Chair of 8 NIH-funded cooperative group trials (5 NRG Oncology, 1 SWOG, 1 ECOG-ACRIN, 1 PCG). He is a three-time winner of the Association of Residents in Radiation Oncology (ARRO) Educator of the Year Award, and he has been elected for Fellowship in the American College of Radiation Oncology (FACRO).


Dr. Simone is the Proton Collaborative Group (PCG) President of the Board of Directors and Chairs the PCG Executive Committee and PCG Lung Committee. He is the Vice Chair of NRG Oncology’s Radiation Oncology Committee and Chair of NRG Oncology’s Particle Therapy Work Group. Dr. Simone also Chairs/Co-Chairs the American Society for Radiation Oncology (ASTRO) Lung Resource Panel Committee; ASTRO Blue Ribbon Lung Panel; ASTRO Small Cell Lung Cancer Guidelines Committee; American Radium Society (ARS) Appropriate Use Criteria Thoracic Committee; Particle Therapy Co-Operative Group (PTCOG) Gastrointestinal Subcommittee; PTCOG Skull Base/Central Nervous System, Sarcoma Subcommittee; American College of Radiation Oncology (ACRO) Recruitment Subcommittee; ACRO Annual Meeting Abstracts Committee; National Cancer Institute/Radiosurgery Society (RSS) GRID-Lattice-Microbeam-Flash Radiotherapy Clinical Working Group; Varian FlashForward Consortium Clinical Committee; and Varian Connect Proton User Group.  He is the Editor-in-Chief of Annals of Palliative Medicine and on the Editorial Boards of  Cancers, Translational Lung Cancer ResearchFrontiers in Oncology, Journal of Thoracic Disease Annals of Translational Medicine, and Therapeutic Radiology and Oncology, among others.


Dr. Simone was recognized by Crain’s New York on its 2021 Notable in Healthcare list and by

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